Endocrine Abstracts

Introduction and aim: Dopamine agonists (DA) are prescribed as first-line treatment for prolactinomas and are generally effective and well tolerated. However, the degree and quickness of therapeutic response is variable among patients. The aim of this work is to study the predictive factors of biological remission in patients with prolactinoma treated with DA. Methods: A single-center, retrospective and analytical study of patients with prolactinoma foll...

Introduction: Empty sella syndrome (ESS) is a rare condition in which the sella turcica is partially or completely filled with cerebrospinal fluid. It can be primary or secondary. Ophthalmologic involvement is rare in primary empty sella Syndrome. It is described in only 1.6 to 16% of cases. Patients and methods: We report a retrospective study of 46 cases of ESS collected in the endocrinology department over the period from 1991 to 2020. The clinical an...

Introduction: Diabetes insipidus (DI) is a rare pathology. The advent of hypothalamic-pituitary MRI has made it possible to make a positive diagnosis by avoiding the water restriction test (WRT). The etiological diagnosis is still a challenge in view of the diversity of diseases involved, which influences the therapeutic management and prognosis.Work Objectives: The objectives of our work were to describe the clinical, paraclinical and genetic features o...

Introduction: Pituitary stalk thickening (PST) is often identified on magnetic resonance imaging (MRI), either incidentally or during diagnostic workup of hypopituitarism. Currently, there is no unified standard for the definition of PST. As a reference, a pituitary stalk with width over 3 mm has been used as the diagnostic criterion for PST in recent years. The disease spectrum of PST is quite diverse and can be grouped into three broad categories: neoplastic, inflammatory an...

Introduction: Mixed connective tissue disease (MCTD), also known as Sharp´s syndrome is a rare autoimmune disease (AD), characterized by the presence of high titers of a distinctive autoantibody: ribonucleoprotein auto-antibody (anti-RNP). It presents with varied overlapping symptoms of different connective tissue disorders which may appear sequentially over time. As other AD, MCTD may be associated with one or more AD, such as autoimmune thyroid disorders (AITD).<p c...

Introduction: Autoimmune hepatitis (AIH) is a generally progressive and chronic liver disease that can occur both in children and adults. Although the cause of AIH is unknown, aberrant auto-reactivity is thought to have a role in its pathogenesis. The diagnosis is based on clinical presentation, biological and histological findings. Like other autoimmune diseases (AD), AIH can be associated with one or more AD either organ-specific or non-organ specific AD. <p class="abste...

Introduction: Graves’ disease (GD) is the most common cause of hyperthyroidism in pediatric patients, up to 95% in some studies.Observation: We report the observation of a 6-year-old female who consulted for a behavioral disorder made of agitation and lack of concentration. She had a family history of autoimmune thyroid disease. On examination, an accelerated statural growth rate of +2DS was noted. She had a significant palpebral retraction without ...

Introduction: Cardiothyreosis is the consequence of the effects of excess free thyroid hormones on the vascular wall and myocardium. This complication is the most serious aspect of hyperthyroidism. Rhythm disorders and heart failure are the most frequently noted. The prevalence of coronary insufficiency is lower. The aim of this study is to evaluate the characteristics of coronary insufficiency in patients with hyperthyroidism.Method: This is a retrospec...

Amiodarone is considered by many the most potent antiarrhythmic drug. The other side of the coin is that it’s associated with many side effects including disturbances in the thyroid function, which can be seen in 14 to 18 % of the cases (1). This case is about a 56-year-old male patient with a history of mitral valve disease who was on Amiodarone for 3 years. His personal history was notable with Epilepsy of unknow etiology for which he was on sodium valproate. During fol...

Introduction: Addison disease (AD) is associated with high risk of decreased bone mineral density (BMD) and osteoporosis. Causes are complex, including lifelong glucocorticoid replacement therapy. Several studies have pointed a significant relationship between glucocorticoid dose and low BMD in patients with AD. The aim of our study is to assess the impact of glucocorticoid replacement dose on BMD among Tunisian patients with AD.Patients and Methods: We ...